Seminar: Protein folding and escape at the ribosomal exit tunnel

Welcome to our TIAS-PRATI seminar.

Speaker: Assoc. Prof. Trịnh Xuân Hoàng
Institute of Physics, Vietnam Academy of Science and Technology

Time: 9:00 Tuesday, 10/12/2019.

Location: Room 607, Building A2, Phenikaa University
                Yen Nghia, Ha Dong, Hanoi

Title: Protein folding and escape at the ribosomal exit tunnel


In this talk, I will introduce our current theoretical approaches to studies of biomolecules and soft matter systems. As a detailed example I will discuss the post-translational folding and escape of nascent proteins at the ribosomal exit tunnel with the help of coarse-grained molecular dynamics simulations and a simple diffusion model based on the Smoluchowski equation. There will be relevant issues in this discussion such as the coupling between the folding and escape processes, the role of the size and shape of the tunnel. In contrast to the multiple pathways of protein refolding in solution, folding at the tunnel is shown to follow one or two downhill pathways without kinetic traps. Our analysis of the protein diffusion suggests that the length of the ribosomal exit tunnel has been chosen by evolution to facilitate both the efficient escape and the correct folding of nascent proteins.

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