Seminar: Protein folding and escape at the ribosomal exit tunnel

Trân trọng kính mời các đồng nghiệp tới tham dự buổi seminar của trường Đại học Phenikaa.

Người trình bày: PGS. TS. Trịnh Xuân Hoàng
                           Institute of Physics, Vietnam Academy of Science and Technology
Thời gian: 9:00am, ngày 10/12/2019.

Địa điểm: Phòng 607, nhà A2, trường Đại học Phenikaa
                Yên Nghĩa, Hà Đông, Hà Nội

Tiêu đề: Protein folding and escape at the ribosomal exit tunnel

Tóm tắt:
In this talk, I will introduce our current theoretical approaches to studies of biomolecules and soft matter systems. As a detailed example I will discuss the post-translational folding and escape of nascent proteins at the ribosomal exit tunnel with the help of coarse-grained molecular dynamics simulations and a simple diffusion model based on the Smoluchowski equation. There will be relevant issues in this discussion such as the coupling between the folding and escape processes, the role of the size and shape of the tunnel. In contrast to the multiple pathways of protein refolding in solution, folding at the tunnel is shown to follow one or two downhill pathways without kinetic traps. Our analysis of the protein diffusion suggests that the length of the ribosomal exit tunnel has been chosen by evolution to facilitate both the efficient escape and the correct folding of nascent proteins.

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